5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide

Name	Selonsertib
Synonyms	ASK-1 GS-4497 GS-4997 GS 4997 Selonsertib GS4997 SELONSERTIB Selonsertib GS-4997 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide 5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide
CAS	1448428-04-3

Molecular Formula	C24H24FN7O
Molar Mass	445.49
Density	1.39±0.1 g/cm3(Predicted)
Melting Point	>180°C (dec.)
Solubility	DMSO: ≥ 31 mg/mL
Appearance	solid
Color	White
pKa	11.21±0.70(Predicted)
Storage Condition	-20°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vivo study	GS-4997 are orally biologically active. After oral administration, GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, inhibiting its phosphorylation and activation. GS-4997 inhibit the phosphorylation of ASK1 downstream kinases, such as c-Jun N-terminal kinases (JNKs) and p38 MAPK. By inhibiting the activation of ask1-dependent signal transduction pathway, GS-4997 can prevent the production of inflammatory cytokines, down-regulate the expression of genes involved in the process of fibrosis, inhibit excessive apoptosis and cell proliferation.

Last Update：2024-01-02 23:10:35

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Product Name: Selonsertib Visit Supplier Webpage Request for quotation
CAS: 1448428-04-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide Request for Quotation